Disrupted connectivity in Parkinson’s disease (PD) with the probable Rapid eye movement behavior disorder ( RBD)

Rapid eye movement sleep behavior disorder ( RBD) is a kind of sleep disorder in which a person experiences some physical movements and unpleasant dreams with vocal sounds.[1]

Parkinson’s disease (PD) is a brain disorder that brings difficulty in walking, balance and coordination. [2]

This new published study has checked out the functional connectivity in PD with probable Rapid eye movement sleep behavior disorder ( RBD). The whole brain has been explored in this research with the usage of network-based and graphic- theoretical approaches.  

The study consisted of 30 healthy controls, 32 PD without probable RBD and 27 PD with probable RBD( PD- pRBD).

The evaluations demonstrated the functional connectivity reduction in the PD- pRBD group in comparison with healthy controls. This reductions were mainly in the cingulate area with the temporal, frontal, insular, and thalamic region. (p<0.001)

In addition, the PD- pRBD group illustrated the functional connectivity decline between right ventral posterior cingulate and left medial precuneus compared with PD- non pRBD( p<0.05).

Also, researchers found the increased normalized characteristic path length in PD- probable Rapid eye movement sleep behavior disorder ( RBD) which means that the  connectivity strength from reduced connections is correlated with visuprepectual tasks. 

Moreover, It can be concluded that the normalized characteristics path length is correlated with processing speed and verbal memory tasks. This finding is an indication of the existence of disrupted functional connectivity in PD-pRBD.

References:

1:https://www.mayoclinic.org/diseases-conditions/rem-sleep-behavior-disorder/symptoms-causes

2:https://www.nia.nih.gov/health/parkinsons-disease

3: Disrupted functional connectivity in PD with probable RBD and its cognitive

Contact: Arezoo Montazeri

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